Investigating interferon type I responses in patients with suspected giant cell arteritis and polymyalgia rheumatica.

ABSTRACT: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related inflammatory disorders. Easily measurable biomarkers defining active disease and identifying patients in need of glucocorticoid sparing treatment options are highly desired. Interferon Type I (IFN-I) might be involved in disease pathology; however, evidence is limited. This study explores a systemic IFN-I signature and expression of IFN-I markers in GCA and PMR patients. Treatment naive GCA and PMR patients, and PMR patients with glucocorticoid treatment were included. Patients suspected of but not diagnosed with GCA were used as controls. Five relevant IFN-I-stimulated genes were identified in literature, and relative expression levels were determined using quantitative reverse transcription polymerase chain r

SUBMITTER: van Nieuwland M 

PROVIDER: S-EPMC11557144 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature