Understanding the relationship between breast cancer, immune checkpoint inhibitors, and gut microbiota: a narrative review.

ABSTRACT:

Background and objective

The composition of gut microbiota plays an important role in predicting and influencing outcomes of cancer treated with immunotherapy. Our objective is to summarize the role of gut microbiota and immunotherapy in breast cancer.

Methods

A systematic search from inception until July 2024 of key search terms including immunity, breast neoplasm, gastrointestinal microbiome/microbiota, fecal microbiota transplantation, pro- and prebiotics, antibiotics and immunotherapy using EMBASE, MEDLINE and CENTRAL was conducted. The results were screened by two reviewers independently and synthesized and presented descriptively.

Key content and findings

Thirteen studies (5 clinical, 8 pre-clinical) met the eligibility criteria and were published from 2020-2024

SUBMITTER: Hrubesz G 

PROVIDER: S-EPMC11557166 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature