Reduced p63 expression is linked to unfavourable prognosis in muscle-invasive urothelial carcinoma of the bladder.

ABSTRACT:

Objective

There is a shortage of established prognostic biomarkers in bladder cancer. One candidate is tumour protein 63 (p63), a transcription factor of the p53 gene family that is expressed in the normal urothelium. Recently proposed RNA expression-based molecular classifiers of bladder cancer identified high p63 expression as a component of a basal/squamous subtype linked to poor patient prognosis.

Methods

In this study, p63 protein expression was analysed by immunohistochemistry on more than 2500 urothelial bladder carcinomas in a tissue microarray format to determine its relationship with clinicopathological parameters of disease progression and patient outcome.

Results

Nuclear p63 staining was seen in all cells of normal urothelium and at elevated levels in pTaG

SUBMITTER: Furlano K 

PROVIDER: S-EPMC11557268 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature