Taurine/chenodeoxycholic acid ratio as a potential serum biomarker for low vitamin B₁₂ levels in humans.

ABSTRACT: Deficiency of vitamin B₁₂ (B₁₂ or cobalamin), an essential water-soluble vitamin, leads to neurological damage, which can be irreversible and anaemia, and is sometimes associated with chronic disorders such as osteoporosis and cardiovascular diseases. Clinical tests to detect B₁₂ deficiency lack specificity and sensitivity. Delays in detecting B₁₂ deficiency pose a major threat because the progressive decline in organ functions may go unnoticed until the damage is advanced or irreversible. Here, using targeted unbiased metabolomic profiling in the sera of subjects with low B₁₂ levels v control individuals, we set out to identify biomarker(s) of B₁₂ insufficiency. Metabolomic profiling identified seventy-seven metaboli

SUBMITTER: Baghel M 

PROVIDER: S-EPMC11557292 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature