Local delivery of soluble fractalkine (CX3CL1) peptide restores ribbon synapses after noise-induced cochlear synaptopathy.

ABSTRACT: Cochlear ribbon synapses between sensory inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are vulnerable to rapid and primary damage and/or loss due to noise overexposure. Such damaged ribbon synapses can repair spontaneously in mouse and guinea pig. However, the mechanisms for synaptic repair are unclear. Previously, we have demonstrated a critical role for the fractalkine signaling axis (CX₃CL1-CX₃CR1) in synaptic repair, wherein noise-damaged ribbon synapses are spontaneously repaired in the presence of fractalkine receptor (CX₃CR1) expressed by cochlear macrophages. Here, we examined whether local administration of chemokine fractalkine ligand (CX₃CL1 or FKN) in the form of a peptide is effective in restoring synapses and hearing lo

SUBMITTER: Manickam V 

PROVIDER: S-EPMC11557324 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature