Correlations between coagulation abnormalities and inflammatory markers in trauma-induced coagulopathy.

ABSTRACT:

Introduction

In multiple trauma patients, the occurrence of trauma-induced coagulopathy (TIC) is closely associated with tissue damage and coagulation function abnormalities in the pathophysiological process.

Methods

This study established a multiple trauma and shock model in Sprague-Dawley (SD) rats and comprehensively utilized histological staining and radiographic imaging techniques to observe injuries in the intestine, liver, skeletal muscles, and bones. Monitoring activated partial thromboplastin time (APTT), platelet (PLT) count, respiratory rate, blood pressure, and other physiological indicators revealed time-dependent alterations in coagulation function and physiological indicators. Enzyme-linked immunosorbent assay (ELISA) measurements of inflammatory factors Tumor

SUBMITTER: Wen K 

PROVIDER: S-EPMC11557354 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature