Microbiome Geographic Population Structure (mGPS) Detects Fine-Scale Geography.

ABSTRACT: Over the past decade, sequencing data generated by large microbiome projects showed that taxa exhibit patchy geographical distribution, raising questions about the geospatial dynamics that shape natural microbiomes and the spread of antimicrobial resistance genes. Answering these questions requires distinguishing between local and nonlocal microorganisms and identifying the source sites for the latter. Predicting the source sites and migration routes of microbiota has been envisioned for decades but was hampered by the lack of data, tools, and understanding of the processes governing biodiversity. State-of-the-art biogeographical tools suffer from low resolution and cannot predict biogeographical patterns at a scale relevant to ecological, medical, or epidemiological applications. Analyzin

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11557374 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature