Association between focal amyloid deposition and cognitive impairment in individuals below the amyloid threshold.

ABSTRACT:

Purpose

This study aimed to investigate the characteristics of individuals with amyloid levels below the threshold. To achieve this, we differentiated between two groups: those with global amyloid negativity but focal deposition [G(-)F(+)] and those without focal deposition [G(-)F(-)].

Materials and methods

A total of 2,677 participants were diagnosed with cognitive unimpairment (CU) or mild cognitive impairment (MCI). MRI-based regional centiloid (CL) values were used to establish threshold values for each brain region. After applying a cutoff of 20 rdcCL to identify amyloid positivity, participants who were globally amyloid-negative were grouped into three categories: those who showed focal amyloid uptake [G(-)F(+)], individuals without focal amyloid deposition but with re

SUBMITTER: Ham H 

PROVIDER: S-EPMC11557402 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature