Case report: Pediatric hepatopulmonary syndrome despite strict weight control after craniopharyngioma surgery.

ABSTRACT: Childhood-onset craniopharyngiomas, though rare, are intracranial malformations that can cause obesity by disrupting the hypothalamus, a condition that often persists even after tumor resection. This severe obesity increases the risk of diabetes and fatty liver disease in childhood. Concurrently, panhypopituitarism, including growth hormone (GH) deficiency, may develop. Notably, some individuals with GH deficiency may exhibit a normal growth rate, making GH therapy unnecessary for growth purposes. However, in these cases, GH therapy may still be beneficial in preventing the progression of nonalcoholic fatty liver disease or nonalcoholic steatohepatitis. Although weight management is traditionally considered the gold standard for preventing liver cirrhosis, its effectiveness can be limited

SUBMITTER: Yoshikawa S 

PROVIDER: S-EPMC11557431 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature