CardioMEA: comprehensive data analysis platform for studying cardiac diseases and drug responses.

ABSTRACT:

Introduction

In recent years, high-density microelectrode arrays (HD-MEAs) have emerged as a valuable tool in preclinical research for characterizing the electrophysiology of human induced pluripotent stem-cell-derived cardiomyocytes (iPSC-CMs). HD-MEAs enable the capturing of both extracellular and intracellular signals on a large scale, while minimizing potential damage to the cell. However, despite technological advancements of HD-MEAs, there is a lack of effective data-analysis platforms that are capable of processing and analyzing the data, particularly in the context of cardiac arrhythmias and drug testing.

Methods

To address this need, we introduce CardioMEA, a comprehensive data-analysis platform designed specifically for HD-MEA data that have been obtained from iPSC

SUBMITTER: Lee J 

PROVIDER: S-EPMC11557525 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature