Subtractive genomics and comparative metabolic pathways profiling revealed novel drug targets in Ureaplasma urealyticum.

ABSTRACT:

Introduction

Ureaplasma urealyticum is a commensal organism found in the human lower genitourinary tract, which can cause urogenital infections and complications in susceptible individuals. The emergence of antibiotic resistance, coupled with the absence of vaccines, underscores the necessity for new drug targets to effectively treat U. urealyticum infections.

Methods

We employed a subtractive genomics approach combined with comparative metabolic pathway analysis to identify novel drug targets against U. urealyticum infection. The complete proteomes of 13 Ureaplasma strains were analyzed using various subtractive genomics methods to systematically identify unique proteins. Subsequently, the shortlisted proteins were selected for further structure-based s

SUBMITTER: Chen L 

PROVIDER: S-EPMC11557531 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature