Nonlinear pathological trajectory of a high-myopia C57/BL6J mouse model induced by form deprivation.

ABSTRACT:

Introduction

To establish a high myopia model in C57BL/6J mice with monocular form deprivation myopia (FDM) and investigate its ocular structure pathological trajectory.

Methods

Healthy 3-week-old C57BL/6J mice were divided into an FDM group (n = 36) and a control group (n = 24). The left eyes of the FDM group were patched, while the right eyes served as controls. Biometric parameters and fundus morphology were assessed at baseline and after 4, 8, and 12 weeks of form deprivation.

Results

Significant differences were observed in the deprived eyes, including longer axial length, higher refractive power, deeper vitreous chambers, thinner retina, choroid, and sclera, and smaller scleral fibers' diameters under a transmission electron microscope. Retinal vascular area pro

SUBMITTER: Wen Y 

PROVIDER: S-EPMC11557532 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature