Integrated multi-omics identifies pathways governing interspecies interaction between A. fumigatus and K. pneumoniae.

ABSTRACT: Polymicrobial co- and superinfections involving bacterial and fungal pathogens pose serious challenges for diagnosis and therapy, and are associated with elevated morbidity and mortality. However, the metabolic dynamics of bacterial-fungal interactions (BFI) and the resulting impact on disease outcome remain largely unknown. The fungus Aspergillus fumigatus and the bacterium Klebsiella pneumoniae are clinically important pathogens sharing common niches in the human body, especially in the lower respiratory tract. We have exploited an integrated multi-omics approach to unravel the complex and multifaceted processes implicated in the interspecies communication involving these pathogens in mixed biofilms. In this setting, A. fumigatus responds to the bacterial challenge by rewiring its metabo

SUBMITTER: Bitencourt T 

PROVIDER: S-EPMC11557599 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature