A statistical mechanics investigation of unfolded protein response across organisms.

ABSTRACT: Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical threshold. It maintains cell homeostasis by enhancing protein folding, initiating quality control, and activating degradation pathways when damage is irreversible. This response functions as a dynamic signaling network, with proteins as nodes and their interactions as edges. We analyze these protein-protein networks across different organisms to understand their intricate intra-cellular interactions and behaviors. In this work, analyzing twelve organisms, we assess how fundamental measures in network theory can individuate seed proteins and spe

SUBMITTER: Luchetti N 

PROVIDER: S-EPMC11557608 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature