Motor learning promotes regionally-specific spindle-slow wave coupled cerebral memory reactivation.

ABSTRACT: Sleep is essential for the optimal consolidation of newly acquired memories. This study examines the neurophysiological processes underlying memory consolidation during sleep, via reactivation. Here, we investigated the impact of slow wave - spindle (SW-SP) coupling on regionally-task-specific brain reactivations following motor sequence learning. Utilizing simultaneous EEG-fMRI during sleep, our findings revealed that memory reactivation occured time-locked to coupled SW-SP complexes, and specifically in areas critical for motor sequence learning. Notably, these reactivations were confined to the hemisphere actively involved in learning the task. This regional specificity highlights a precise and targeted neural mechanism, underscoring the crucial role of SW-SP coupling. In addition, we o

SUBMITTER: Baena D 

PROVIDER: S-EPMC11557691 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature