Oral Bacillus subtilis spores-based vaccine for mass vaccination against porcine reproductive and respiratory syndrome.

ABSTRACT: Porcine reproductive and respiratory syndrome (PRRS) poses a significant challenge in the global swine industry, leading to substantial economic losses and reproductive and respiratory complications. The causative agent, PRRS virus (PRRSV), with its high mutation rate, complicates the development of universally effective vaccines. Furthermore, current PRRS vaccines are limited by high costs and complex administration methods. Therefore, in this study, we aimed to develop an innovative Bacillus subtilis spore-based oral vaccine targeting PRRS. Their oral administration was evaluated in mice and pigs, and blood, saliva, feces, and bronchoalveolar lavage fluid samples were collected for further analyses. Our vaccine induced IgG and IgA immune responses in both models, with swine demonstrating

SUBMITTER: Min H 

PROVIDER: S-EPMC11557699 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature