Core-shell upconversion nanoparticles with suitable surface modification to overcome endothelial barrier.

ABSTRACT: Upconversion nanoparticles (UCNPs), capable of converting near-infrared (NIR) light into high-energy emission, hold significant promise for bioimaging applications. However, the presence of tissue barriers poses a challenge to the effective delivery of nanoparticles (NPs) to target organs. In this study, we demonstrate the core-shell UCNPs modified with cationic biopolymer, i.e., N, N-trimethyl chitosan (TMC), can overcome endothelial barriers. The core-shell UCNP is composed of NaGdF₄: Yb³⁺,Tm³⁺ (16.7 ± 2.7 nm) as core materials and silica (SiO₂) shell. The average particle size of UCNPs@SiO₂ is estimated at 26.1 ± 3.7 nm. X-ray diffraction (XRD), transmission electron microscopy (TEM) and element mapping shows the formation of hexago

SUBMITTER: Lu C 

PROVIDER: S-EPMC11557796 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature