Expression pattern of long non-coding RNAs in treatment-naive and medicated schizophrenia patients.

ABSTRACT: Schizophrenia is a disabling mental disorder that affects 1% of people over their lifetime. The etiology and mechanism of schizophrenia are very complex, and many genes are involved in many different signaling pathways in the etiology of this disease. According to recent studies, one of the important mechanisms altered in this disorder is the regulation of immune system and the inflammation mechanism. In the present study, we evaluated the peripheral blood expression pattern of four lncRNAs and three protein-coding genes in the treatment- naïve patients, and medicated patients compared with sex and age-matched controls. In the medicated-patients, expression levels of IFNG, IL18RAP, AC007278.2 were significantly up-regulated (P < 0.05); and the expression level of IFNG-AS1-001 was significa

SUBMITTER: Javidi Aghdam K 

PROVIDER: S-EPMC11557838 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature