Gastrointestinal germinal center B cell depletion and reduction in IgA⁺ plasma cells in HIV-1 infection.

ABSTRACT: Gastrointestinal (GI) B cells and plasma cells (PCs) are critical to mucosal homeostasis and the host response to HIV-1 infection. Here, high-resolution mapping of human B cells and PCs sampled from the colon and ileum during both viremic and suppressed HIV-1 infection identified a reduction in germinal center (GC) B cells and follicular dendritic cells (FDCs) during HIV-1 viremia. Immunoglobulin A-positive (IgA⁺) PCs are the major cellular output of intestinal GCs and were significantly reduced during viremic HIV-1 infection. PC-associated transcriptional perturbations, including type I interferon signaling, persisted in antiretroviral therapy (ART)-treated individuals, suggesting ongoing disruption of the intestinal immune milieu during ART. GI humoral immune perturbations wer

SUBMITTER: Cossarini F 

PROVIDER: S-EPMC11557871 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature