Genome-wide analysis of quorum sensing regulon in marine fish pathogen Vibrio scophthalmi.

ABSTRACT: Opportunistic fish pathogen Vibrio scophthalmi frequently infects olive flounder and turbot, which are primary marine species cultured for seafood production in Far East Asia. These infections cause substantial yield reductions and significant economic losses. Although quorum sensing (QS) genes were previously reported in V. scophthalmi, the impacts of QS on genome-wide gene expression and consequent behaviors and physiological traits have remained largely unexplored. In this study, we conducted genomic and transcriptomic analyses to uncover the global regulatory network governed by LuxR_Vs, a QS master regulator in V. scophthalmi. By comparing the wild-type strain and a luxR_Vs deletion mutant strain, we found that LuxR_Vs positively regulates biosynthetic ge

SUBMITTER: Seok B 

PROVIDER: S-EPMC11558012 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature