Sequential Deactivation Across the Hippocampus-Thalamus-mPFC Pathway During Loss of Consciousness.

ABSTRACT: How consciousness is lost in states such as sleep or anesthesia remains a mystery. To gain insight into this phenomenon, concurrent recordings of electrophysiology signals in the anterior cingulate cortex and whole-brain functional magnetic resonance imaging (fMRI) are conducted in rats exposed to graded propofol, undergoing the transition from consciousness to unconsciousness. The results reveal that upon the loss of consciousness (LOC), there is a sharp increase in low-frequency power of the electrophysiological signal. Additionally, fMRI signals exhibit a cascade of deactivation across a pathway including the hippocampus, thalamus, and medial prefrontal cortex (mPFC) surrounding the moment of LOC, followed by a broader increase in brain activity across the cortex during sustained uncons

SUBMITTER: Chen X 

PROVIDER: S-EPMC11558098 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature