Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.

ABSTRACT: Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during missions to the Moon and Mars. Experimental models capable of recapitulating human physiology are critical to understanding the effects of radiation on human organs and developing radioprotective measures against space travel exposures. The effects of systemic radiation are studied using a multi-organ-on-a-chip (multi-OoC) platform containing engineered tissue models of human bone marrow (site of hematopoiesis and acute radiation damage), cardiac muscle (site of chronic radiation damage) and liver (site of metabolism), linked by vascular circulation with an endothelial barrier separating individual tissue chambers from the vascular perfusate. Following protracted neutron radiation, the most damaging

SUBMITTER: Tavakol DN 

PROVIDER: S-EPMC11558103 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature