Different Biomechanical Cell Behaviors in an Epithelium Drive Collective Epithelial Cell Extrusion.

ABSTRACT: In vertebrates, many organs, such as the kidney and the mammary gland form ductal structures based on the folding of epithelial sheets. The development of these organs relies on coordinated sorting of different cell lineages in both time and space, through mechanisms that remain largely unclear. Tissues are composed of several cell types with distinct biomechanical properties, particularly at cell-cell and cell-substrate boundaries. One hypothesis is that adjacent epithelial layers work in a coordinated manner to shape the tissue. Using in vitro experiments on model epithelial cells, differential expression of atypical Protein Kinase C iota (aPKCi), a key junctional polarity protein, is shown to reinforce cell epithelialization and trigger sorting by tuning cell mechanical properties at th

SUBMITTER: Balasubramaniam L 

PROVIDER: S-EPMC11558136 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature