Two-Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis-Dominated Sonopiezoelectric Cancer Therapy.

ABSTRACT: Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is hindered by the long distance of charge migration from the bulk to the material surface. Herein, atomically thin Bi₂O₂(OH)(NO₃) (AT-BON) nanosheets are rationally engineered through disrupting the weaker hydrogen bonds within the [OH] and [NO₃] layer in the bulk material. The ultrathin structure of AT-BON piezocatalytic nanosheets shortens the migration distance of carriers, expands the specific surface area, and accelerates the charge transfer efficiency, showc

SUBMITTER: Deng R 

PROVIDER: S-EPMC11558157 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature