Chemotherapy-induced increase in CD47 expression in epithelial ovarian cancer.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy with limited treatment options. CD47 is a critical immune checkpoint for tumor immune evasion and has been targeted in various clinical trials. This study aimed to assess the impact of chemotherapy on CD47 expression in EOC in order to determine the potential and optimal timing of CD47-targeted therapy in ovarian cancer. We analyzed the expression of CD47 in ovarian cancer and the effect of chemotherapy on the expression of CD47 in ovarian cancer tissues. Furthermore, we investigated the effect of chemotherapy on the expression of CD47 in ovarian cancer cells.

Methods

CD47 expression was examined using immunohistochemistry (IHC) of specimens from 78 patients with EOC who underwent neo

SUBMITTER: Zhao L 

PROVIDER: S-EPMC11558286 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature