Diagnostic challenges in calcitonin negative medullary thyroid carcinoma: a systematic review of 101 cases.

ABSTRACT:

Background

Calcitonin-negative medullary thyroid carcinoma (CNMTC), a rare form of MTC characterized by classic histopathology with normal serum calcitonin levels, presents a diagnostic challenge. This systematic review aims to summarize the clinical and pathological features of CNMTC and evaluate the utility of alternative biochemical markers.

Methods

Eligibility criteria for this systematic review included patients with a confirmed histopathological diagnosis of medullary thyroid carcinoma (MTC), normal preoperative serum calcitonin levels, or negative immunohistochemical (IHC) stain for calcitonin. A comprehensive electronic search strategy was employed on PubMed, Scopus, and Embase databases from January 1^st, 1950, to March 9^th, 2023.

Results

SUBMITTER: Abaalkhail M 

PROVIDER: S-EPMC11558288 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature