The antimicrobial effect of <i>Curcuma longa</i> and <i>Allium sativum decoction</i> in rats explains its utility in wound care.

ABSTRACT:

Objective

In South Asia, Curcuma longa and Allium sativum are extensively used as household remedies for wound care for veterinary and human infectious diseases. However, little pharmacologic data is present to support this folklore. A series of in vitro and in vivo experiments were conducted to validate the folkloric practice of these herbs.

Methods

In vitro experiments, phytochemistry, polyphenolic content, acute dose dermal toxicity, antimicrobial activity, and antioxidant assays were conducted. For in vivo experiments, the decoction was prepared and tested for a wound cure against an experimentally induced excision wound on the dorsal region of rats under ketamine anesthesia. Rats were divided into five groups (5 rats in e

SUBMITTER: Khan MK 

PROVIDER: S-EPMC11558388 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature