Unveiling the oncogenic significance of thymidylate synthase in human cancers.

ABSTRACT:

Objective

Thymidylate synthase (TYMS) constitutes a pivotal and potent target in the context of chemoresistance. However, the oncogenic role of TYMS has received insufficient attention.

Methods

Leveraging data from the Cancer Genome Atlas (TCGA) and various public databases, we conducted an extensive investigation into the oncogenic role of TYMS across 33 cancer types. Subsequently, TYMS was inhibited using small interfering RNA (siRNA) in four different cell lines, and cell proliferation and migration were assessed using CellTiter-Glo and Transwell assays.

Results

TYMS exhibited pronounced expression across a spectrum of cancers and demonstrated associations with clinical outcome in diverse cancer patient cohorts. Furthermore, genetic alterations were identified as p

SUBMITTER: Geng Y 

PROVIDER: S-EPMC11558401 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature