Development and validation of a prognostic nomogram based on the hub genes of patients with hypertensive intracerebral hemorrhage.

ABSTRACT:

Objective

Hypertensive intracerebral hemorrhage (HICH) is frequently associated with high disability, high mortality, and poor prognosis. The present study aimed to identify genes associated with HICH to construct prognostic models to improve accuracy in predicting HICH prognosis.

Methods

Hub genes were identified by screening out differentially expressed genes from data in the Gene Expression Omnibus database and conducting weighted gene co-expression network analysis. 68 patients with HICH were recruited and categorized based on prognosis. The univariate logistic, least absolute shrinkage and selection operator, and multivariate logistic regression models were then established based on clinical data and the identified hub genes. A prognostic model was constructed based on

SUBMITTER: Sun R 

PROVIDER: S-EPMC11558421 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature