Skeletal phenotypes in postmenopausal women affected by primary hyperparathyroidism.

ABSTRACT:

Purpose

The current primary hyperparathyroidism (PHPT) presents as a mild disease. We explored skeletal phenotypes in postmenopausal women affected by PHPT, focusing on fracture prevalence.

Methods

PHPT women were retrospectively evaluated at four Italian centers for osteoporosis management (two centers in Milan, n = 244; Cuneo, n = 128; Pisa, n = 131). Data collected from clinical records were analyzed by hierarchical clusterization.

Results

Considering the whole PHPT series [n = 503, aged 67.0 (61.0-74.0) years], 90% had low bone mineral density (BMD) and approximately 30% reported at least one fracture. Vertebral fractures were associated with older age and lower hypophosphatemia, while women with appendicular fractures were younger with

SUBMITTER: Corbetta S 

PROVIDER: S-EPMC11558525 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature