Relationships between serotonin 1A receptor DNA methylation, self-reported history of childhood abuse and gray matter volume in major depression.

ABSTRACT:

Background

Early life adversity is a risk factor for psychopathology and is associated with epigenetic alterations in the 5-HT_1A receptor gene promoter. The 5-HT_1A receptor mediates neurotrophic effects, which could affect brain structure and function. We examined relationships between self-reported early childhood abuse, 5-HT_1A receptor promoter DNA methylation, and gray matter volume (GMV) in Major Depressive Disorder (MDD).

Methods

Peripheral DNA methylation of 5-HT_1A receptor promoter CpG sites -681 and -1007 was assayed in 50 individuals with MDD, including 18 with a history of childhood abuse. T1-weighted structural magnetic resonance imaging (MRI) was performed. Voxel-based morphometry (VBM) was quantified in amygdala, hippo

SUBMITTER: Goldenthal AR 

PROVIDER: S-EPMC11558534 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature