Magnetically Driven Hydrogel Surfaces for Modulating Macrophage Behavior.

ABSTRACT: During the host response toward implanted biomaterials, macrophages can shift phenotypes rapidly upon changes in their microenvironment within the host tissue. Exploration of this phenomenon can benefit significantly from the development of adequate tools. Creating cell microenvironment alterations on classical hydrogel substrates presents challenges, particularly when integrating them with cell cultivation and monitoring processes. However, having the capability to dynamically manipulate the cell microenvironment on biomaterial surfaces holds significant potential. We introduce magnetically actuated hydrogels (_MadSurface) tailored to induce reversible stiffness changes on polyacrylamide hydrogel substrates with embedded magnetic microparticles in a time-controllable manner. Our

SUBMITTER: Li L 

PROVIDER: S-EPMC11558558 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature