Comparative <i>In Vivo</i> Biocompatibility of Cellulose-Derived and Synthetic Meshes in Subcutaneous Transplantation Models.

ABSTRACT: Despite the increasing interest in cellulose-derived materials in biomedical research, there remains a significant gap in comprehensive in vivo analyses of cellulosic materials obtained from various sources and processing methods. To explore durable alternatives to synthetic medical meshes, we evaluated the in vivo biocompatibility of bacterial nanocellulose, regenerated cellulose, and cellulose nanofibrils in a subcutaneous transplantation model, alongside incumbent polypropylene and polydioxanone. Notably, this study demonstrates the in vivo biocompatibility of regenerated cellulose obtained through alkali dissolution and subsequent regeneration. All cellulose-derived implants triggered the expected foreign body response in the host tissue, characterized predominantl

SUBMITTER: Peltokallio NMM 

PROVIDER: S-EPMC11558565 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature