<i>In Situ</i> FT-IR Spectroelectrochemistry Reveals Mechanistic Insights into Nitric Oxide Release from Ruthenium(II) Nitrosyl Complexes.

ABSTRACT: Ruthenium(II) tetraamine nitrosyl complexes with N-heterocyclic ligands are known for their potential as nitric oxide (NO^•) donors, capable of releasing NO^• through either direct photodissociation or one-electron reduction of the Ru(II)NO⁺ center. This study delivers a novel insight into the one-electron reduction mechanism for the model complex trans-[Ru^II(NO)(NH₃)₄(py)]³⁺ (RuNOpy, py = pyridine) in phosphate buffer solution (pH 7.4). In situ FT-IR spectroelectrochemistry reveals that the pyridine ligand is readily released upon one-electron reduction of the nitrosyl complex, a finding supported by nuclear magnetic resonance spectroscopy (¹H NMR) and electrochemistry coupled to mass spect

SUBMITTER: Goncalves FS 

PROVIDER: S-EPMC11558665 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature