Interaction of Arginine-Rich Surfactant-like Peptide Nanotubes with Liposomes.

ABSTRACT: The interaction of the surfactant-like peptide (SLP) R₃L₁₂ bearing three cationic arginine residues with model liposomes is investigated in aqueous solution at various pH values, under conditions for which the SLP self-assembles into nanotubes. The structure of liposomes of model anionic lipid DPPG [1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol)], or zwitterionic lipid DPPE [1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine] is probed using small-angle X-ray scattering and cryogenic-transmission electron microscopy. The unilamellar vesicles of DPPG are significantly restructured in the presence of R₃L₁₂, especially at low pH, and multilamellar vesicles of DPPE are also restructured under these conditions. The SLP promotes the

SUBMITTER: Castelletto V 

PROVIDER: S-EPMC11558666 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature