A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria.

ABSTRACT: Identification of bacterial lectins offers an attractive route to the development of new diagnostics, but the design of specific sensors is complicated by the low selectivity of carbohydrate-lectin interactions. Here we describe a glycopolymer-based sensor array which can identify a selection of lectins with similar carbohydrate recognition preferences through a pattern-based approach. Receptors were generated using a polymer scaffold functionalized with an environmentally sensitive fluorophore, along with simple carbohydrate motifs. Exposure to lectins induced changes in the emission profiles of the receptors, enabling the discrimination of analytes using linear discriminant analysis. The resultant algorithm was used for lectin identification across a range of concentrations and within co

SUBMITTER: Leslie KG 

PROVIDER: S-EPMC11558668 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature