A scoping review regarding reproductive capacity modulation based on alpha-ketoglutarate supplementation.

ABSTRACT:

In brief

Alpha-ketoglutarate is a common metabolite in the tricarboxylic acid cycle and is central in modulating the reproductive potential in animal models. The present scoping review systematically covers the spectrum of a wide range of evidence from different viewpoints, focusing on the underlying processes and mechanisms of the developmental framework, aiming to fill the gaps within the existing literature.

Abstract

Alpha-ketoglutarate is an important intermediate molecule in the tricarboxylic acid cycle with a prominent role in distinct biological processes such as cellular energy metabolism, epigenetic regulation, and signaling pathways. We conducted a registered scoping review (OSF: osf.io/b8nyt) to explore the impact of exogenous supplementation on reproductive capab

SUBMITTER: Doroftei B 

PROVIDER: S-EPMC11558802 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature