The impact of age on clinicopathological features and treatment results in patients with localised prostate cancer receiving definitive radiotherapy.

ABSTRACT:

Background

This study assessed the biochemical disease-free survival (bDFS), prostate cancer-specific survival (PCSS), overall survival (OS), and side effects in patients aged < 70 and ≥ 70 years following definitive radiotherapy (RT). It also analysed the correlation between age at diagnosis and clinicopathological characteristics of prostate cancer (PCa).

Methods

The prognostic factors for bDFS, PCSS, and OS were determined through univariable and multivariable analyses. Two age groups were also compared in terms of acute and late grade ≥ 2 genitourinary (GU) and gastrointestinal (GI) toxicities, the predictors of which were determined through logistic regression analysis.

Results

Of the 1,328 patients, 715 (53.8%) and 613 (46.2%) were aged < 70 and ≥ 70 years, resp

SUBMITTER: Onal C 

PROVIDER: S-EPMC11558863 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature