Adipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes.

ABSTRACT: Coronary artery disease has a high mortality rate and is a striking public health concern, affecting a substantial portion of the global population. On the early onset of myocardial ischemia, thrombolytic therapy and coronary revascularization could promptly restore the bloodstream and nutrient supply to the ischemic tissue, efficiently preserving less severely injured myocardium. However, the abrupt re-establishment of blood flow triggers the significant discharge of previously accumulated oxidative substances and inflammatory cytokines, leading to further harm referred to as ischemia/reperfusion (I/R) injury. Diabetes significantly raises the vulnerability of the heart to I/R injury due to disrupted glucose and lipid processing, impaired insulin sensitivity and metabolic signaling, and i

SUBMITTER: Han R 

PROVIDER: S-EPMC11558907 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature