The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence.

ABSTRACT: Candida auris, a multidrug-resistant human fungal pathogen, was first identified in 2009 in Japan. Since then, systemic C. auris infections have now been reported in more than 50 countries, with mortality rates of 30%-60%. A major contributing factor to its high inter- and intrahospital clonal transmission is that C. auris, unlike most Candida species, displays unique skin tropism and can stay on human skin for a prolonged period. However, the molecular mechanisms responsible for C. auris skin colonization, intradermal persistence, and systemic virulence are poorly understood. Here, we report that C. auris Hog1 mitogen-activated protein kinase is essential for efficient skin colonization, intradermal persistence as well as systemic virulence. RNA-s

SUBMITTER: Shivarathri R 

PROVIDER: S-EPMC11558994 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature