EF-hand calcium sensor, EfhP, controls transcriptional regulation of iron uptake by calcium in Pseudomonas aeruginosa.

ABSTRACT: The human pathogen Pseudomonas aeruginosa (Pa) poses a major risk for a range of severe infections, particularly lung infections in patients suffering from cystic fibrosis (CF). As previously reported, the virulent behavior of this pathogen is enhanced by elevated levels of Ca²⁺ that are commonly present in CF nasal and lung fluids. In addition, a Ca²⁺-binding EF-hand protein, EfhP (PA4107), was partially characterized and shown to be critical for the Ca²⁺-regulated virulence in P. aeruginosa. Here, we describe the rapid (10 min, 60 min), and adaptive (12 h) transcriptional responses of PAO1 to elevated Ca²⁺ detected by genome-wide RNA sequencing and show that efhP deletion significantly hindered both rapid and adaptiv

SUBMITTER: Burch-Konda J 

PROVIDER: S-EPMC11559002 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature