T lymphocyte-dependent IL-10 down-regulates a cytokine storm driven by Toxoplasma gondii GRA24.

ABSTRACT: As a model organism in the study of immunity to infection, Toxoplasma gondii has been instrumental in establishing key principles of host anti-microbial defense and its regulation. Here, we employed an attenuated uracil auxotroph strain of Type I Toxoplasma designated OMP to further untangle the early immune response to this parasitic pathogen. Experiments using αβ T cell-deficient Tcrb^-/- mice unexpectedly revealed that an intact αβ T lymphocyte compartment was essential to survive infection with OMP. Subsequent antibody depletion and knockout mouse experiments demonstrated contributions from CD4⁺ T cells and most predominantly CD8⁺ T cells in resistance. Using transgenic knockout mice, we found only a partial requirement for IF

SUBMITTER: Doherty CM 

PROVIDER: S-EPMC11559025 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature