Translation initiation or elongation inhibition triggers contrasting effects on <i>Caenorhabditis elegans</i> survival during pathogen infection.

ABSTRACT: Diverse microbial pathogens are known to attenuate host protein synthesis. Consequently, the host mounts a defense response against protein translation inhibition, leading to increased transcript levels of immune genes. The seemingly paradoxical upregulation of immune gene transcripts in response to blocked protein synthesis suggests that the defense mechanism against translation inhibition may not universally benefit host survival. However, a comprehensive assessment of host survival on pathogens upon blockage of different stages of protein synthesis is currently lacking. Here, we investigate the impact of knockdown of various translation initiation and elongation factors on the survival of Caenorhabditis elegans exposed to Pseudomonas aeruginosa. Intriguingly, we observe op

SUBMITTER: Ghosh A 

PROVIDER: S-EPMC11559039 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature