<i>Aedes aegypti</i> adiponectin receptor-like protein signaling facilitates Zika virus infection.

ABSTRACT: The Aedes aegypti mosquito plays a critical role in the transmission of viral diseases, including Zika virus, which poses significant public health challenges. Understanding the complex interactions between mosquitoes and viruses is paramount for the development of effective control strategies. In this study, we demonstrate that silencing the A. aegypti adiponectin receptor-like protein (AaARLP) results in a reduction of Zika virus infection. Transcriptomic analysis identified alterations in several trypsin genes and further revealed that AaARLP-knockdown mosquitoes had diminished trypsin activity. Moreover, silencing of selected trypsins resulted in a similar delay in Zika virus infection in mosquitoes, further highlighting the connection between the AaARLP and

SUBMITTER: Chen T-Y 

PROVIDER: S-EPMC11559040 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature