The riboflavin biosynthetic pathway as a novel target for antifungal drugs against <i>Candida</i> species.

ABSTRACT: In recent decades, there has been an increase in the occurrence of fungal infections; yet, the arsenal of drugs available to fight invasive infections remains very limited. The development of new antifungal agents is hindered by the restricted number of molecular targets that can be exploited, given the shared eukaryotic nature of fungi and their hosts which often leads to host toxicity. In this paper, we examine the riboflavin biosynthetic pathway as a potential novel drug target. Riboflavin is an essential nutrient for all living organisms. Its biosynthetic pathway does not exist in humans, who obtain riboflavin through their diet. Our findings demonstrate that all enzymes in the pathway are essential for Candida albicans, Candida glabrata, and Saccharomyces cerevisiae.<

SUBMITTER: Nysten J 

PROVIDER: S-EPMC11559065 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature