Cell-based therapies reverse the heart failure-altered right ventricular proteome towards a pre-disease state.

ABSTRACT:

Background

Congenital heart defects can lead to right ventricular (RV) pressure-overload and heart failure. Cell-based therapies, including mesenchymal stromal cells (MSCs) and c-kit positive cells (CPCs) have been studied clinically as options to restore heart function in disease states. Many studies have indicated these cells act through paracrine mechanisms to prevent apoptosis, promote cellular function, and regulate gene/protein expression. We aimed to determine the proteomic response of diseased hearts to cell therapy.

Methods

We utilized a juvenile rat model of RV pressure overload created by banding the pulmonary artery (PAB). Two weeks post-banding, bone marrow-derived mesenchymal stromal cells (MSCs) and 3 populations of CPCs (nCPCs, cCPCs, ES-CPCs) were delivered

SUBMITTER: Makkaoui N 

PROVIDER: S-EPMC11559167 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature