Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic.

ABSTRACT: Peptide drugs have seen rapid advancement in biopharmaceutical development, with over 80 candidates approved globally. Despite their therapeutic potential, the clinical translation of peptide drugs is hampered by challenges in production yields and stability. Engineered bacterial therapeutics is a unique approach being explored to overcome these issues by using bacteria to produce and deliver therapeutic compounds at the body site of use. A key advantage of this technology is the possibility to control drug delivery within the body in real time using genetic switches. However, the performance of such genetic switches suffers when used to control drugs that require post-translational modifications or are toxic to the host. In this study, these challenges were experienced when attempting to

SUBMITTER: Dey S 

PROVIDER: S-EPMC11559228 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature