Impact of nebulization versus metered-dose inhaler utilization on viral particle dispersion in patients with COVID-19.

ABSTRACT:

Background

Conflicting guidance exists regarding the characterization of nebulization as an aerosol-generating procedure and subsequent risk of transmission of SARS-CoV-2 to healthcare workers.

Aim/objective

This study sought to address whether SARS-CoV-2 viral load distribution was impacted by bronchodilator delivery via nebulizer versus metered-dose inhaler (MDI).

Methods

Adults infected with COVID-19 were enrolled and received a single dose of albuterol sulfate nebulized solution (2.5 mg/3 mL via breath-actuated nebulizer with filtered mouthpiece) or albuterol sulfate hydrofluoroalkane inhalation aerosol (90 µg/actuation; two puffs via MDI with spacer) in a randomized crossover sequence. Air and surfaces were sampled at predefined locations within patients' hospita

SUBMITTER: Clemency BM 

PROVIDER: S-EPMC11559436 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature