Vitamin D association with systemic sclerosis and its clinical features: A systematic review, meta-analysis, and meta-regression.

ABSTRACT:

Objectives

The aim of this review was to summarize existing data on the contribution of Vitamin D level and/or deficiency/insufficiency to systemic sclerosis susceptibility and its clinical features.

Methods

An electronic literature search for eligible studies among all papers published prior to 30 June 2024 was conducted through PubMed, EMBASE, Web of science, and Scopus databases. Meta-analyses estimating pooled raw mean differences, odds ratios, and Pearson r together with subgroup analyses and meta-regressions were performed for the association of Vitamin D with susceptibility to systemic sclerosis and disease presentation.

Results

Combined analysis revealed a significant decrease in Vitamin D level in systemic sclerosis patients comparatively to healthy co

SUBMITTER: Dhaouadi T 

PROVIDER: S-EPMC11559530 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature