Accelerated biological aging: unveiling the path to cardiometabolic multimorbidity, dementia, and mortality.

ABSTRACT:

Background

Cardiometabolic multimorbidity (CMM) and aging are increasing public health concerns. This prospective study used UK Biobank cohort to investigate the relationship between biological aging and the trajectory of CMM to dementia and mortality.

Methods

CMM is the coexistence of at least two cardiometabolic diseases (CMD), including stroke, ischemic heart disease, and diabetes. Biological age was calculated using the KDM-BA and PhenoAge algorithms. Accelerated aging indicated biological age advances more rapidly than chronological age.

Results

The study included 415,147 individuals with an average age of 56.5 years. During the average 11-year follow-up period, CMD-free individuals with accelerated aging had a significantly greater risk of CMD (KDM-BA, HR 1.456;

SUBMITTER: He Y 

PROVIDER: S-EPMC11559589 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature